PARP-1 Val762Ala (rs1136410) Gene Polymorphism is Associated with Cancer Incidence in Asian Population: A Meta-Analysis

Authors

  • Anak Agung Gede Cahya Wedanta Faculty of Medicine, Udayana University Author
  • Made Ayu Kurniati Atmaja Faculty of Medicine, Udayana University Author
  • I Gede Bayu Bagus Ananda Radiasa Faculty of Medicine, Udayana University Author
  • Made Dhiyo Wiweka Aryaweda Faculty of Medicine, Udayana University Author
  • Gede Bayu Bramantara Faculty of Medicine, Udayana University Author
  • Ni Nyoman Ayu Dewi Department of Biochemistry, Faculty of Medicine, Udayana University Author
  • I Gede Putu Supadmanaba Department of Biochemistry, Faculty of Medicine, Udayana University Author

Keywords:

PARP-1 Val762Ala (rs1136410) polymorphism, Cancer Incidence, Asian population

Abstract

Introduction: Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in DNA repair mechanism especially in resolving strand break lesion. Genetic variation in form of polymorphism in PARP-1 Val762Ala (rs1136410) may reduce its enzymatic activity and affect cancer susceptibility. This study aimed to analyze the roles of this SNP in cancer development specifically on Asian population.

Methods: A systematic literature search was conducted up to May 2026 using PubMed, PubMed Central, ScienceDirect, and Nature databases. Eligible studies published from 2005 onward investigating the association between PARP-1 Val762Ala polymorphism and cancer incidence in Asian populations were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under different genetic comparison models. Sensitivity analysis and publication bias assessment using Egger’s test were also performed.

Result: Our meta-analysis included 21 articles with 22 studies, comprised of a total of 7,866 cancer cases and 12,086 control. Analysis on 4 model analysis resulted as shown (TT vs TC+CC (OR= 1.09 [0.98; 1.22]; 95% CI)), (CC vs TT/TC (OR= 1.14 [1.00; 1.29]; 95% CI)), (CC vs TT (OR = 1.14 [0.98; 1.33]; 95% CI)), and (TC vs TT (OR = 1.05 [0.92; 1.19]; 95% CI)). Sensitivity analysis and Egger's test showed that results of the meta-analysis were fairly stable.

Conclusion: This study indicated that PARP-1 Val762Ala (rs1136410) gene polymorphism is associated with an increased risk of cancer particularly on CC genotype in Asian population.

Author Biographies

  • Anak Agung Gede Cahya Wedanta, Faculty of Medicine, Udayana University

    Faculty of Medicine, Udayana University

  • Made Ayu Kurniati Atmaja, Faculty of Medicine, Udayana University

    Faculty of Medicine, Udayana University

  • I Gede Bayu Bagus Ananda Radiasa, Faculty of Medicine, Udayana University

    Faculty of Medicine, Udayana University

  • Made Dhiyo Wiweka Aryaweda, Faculty of Medicine, Udayana University

    Faculty of Medicine, Udayana University

  • Gede Bayu Bramantara, Faculty of Medicine, Udayana University

    Faculty of Medicine, Udayana University

  • Ni Nyoman Ayu Dewi, Department of Biochemistry, Faculty of Medicine, Udayana University

    Department of Biochemistry, Faculty of Medicine, Udayana University

  • I Gede Putu Supadmanaba, Department of Biochemistry, Faculty of Medicine, Udayana University

    Department of Biochemistry, Faculty of Medicine, Udayana University

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Published

2026-04-28

Issue

Vol. 2 No. 1 (2026)

Section

Research Articles